De Fauw et al. Nature Medicine (2018): Supplementary Video 2: Wet AMD

Supplementary Video 2 from the article De Fauw et al. “Clinically applicable deep learning for diagnosis and referral in retinal disease”. Nature Medicine (in press) (2018), DOI: 10.1038/s41591-018-0107-6

Choroidal neovascularization (CNV) is the pathognomonic feature of the neovascular (“wet”) form of age-related macular degeneration (AMD) and requires urgent treatment to prevent irreversible visual loss. A 72-year old man presented with a history of reduced vision in his left eye. Best corrected visual acuity in the affected eye was 38 Early Treatment Diabetic Retinopathy Study (ETDRS) letters. The model correctly selects the Most Urgent Diagnosis as “CNV”, suggesting referral to an ophthalmologist on an urgent basis. The model segmentation highlights growth of the neovascular tissue in the sub-retinal pigment epithelium (RPE) space – a so-called fibrovascular pigment epithelium detachment (PED). Subretinal fluid can be seen surrounding the inferior margins of the fibrovascular PED indicating the presence of ongoing CNV leakage.

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