De Fauw et al. Nature Medicine (2018): Supplementary Video 4: DME

Supplementary Video 4 from the article De Fauw et al. “Clinically applicable deep learning for diagnosis and referral in retinal disease”. Nature Medicine (in press) (2018), DOI: 10.1038/s41591-018-0107-6

Accumulation of this fluid in the macula – diabetic macular edema (DME) – is the commonest cause of visual impairment in diabetes. A 54-year old man with diabetes was referred to Moorfields for ophthalmologist review with best corrected visual acuity in the affected eye of 45 ETDRS letters. The model correctly detects the presence of macular retinal edema (MRE) and suggests semi-urgent ophthalmology referral. The model highlights intra-retinal fluid accumulation, with cystoid spaces in both the inner nuclear and outer plexiform layers, and a mixed petaloid/honeycomb appearance on the en face images. There is also an accompanying significant increase in total retinal thickness.

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