De Fauw et al. Nature Medicine (2018): Supplementary Video 6: GA

Supplementary Video 6 from the article De Fauw et al. “Clinically applicable deep learning for diagnosis and referral in retinal disease”. Nature Medicine (in press) (2018), DOI: 10.1038/s41591-018-0107-6

In advanced forms of AMD, geographic atrophy (GA) may sometimes coexist with CNV formation. In such cases, the CNV component may be clinically silent, and the fundus appearance may be limited to that of GA, making the diagnosis difficult. A 84-year old man was referred to Moorfields. Best corrected visual acuity in the affected eye was 1/60. The ground truth diagnosis was GA and routine referral was recommended. While the model correctly diagnoses the presence of GA and drusen, it suggests urgent referral due to the possible presence of CNV. The presence of subretinal hyperreflective on model segmentation is suggestive of previous CNV formation.

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