De Fauw et al. Nature Medicine (2018): Supplementary Video 8: Uncertain case

Supplementary Video 8 from the article De Fauw et al. “Clinically applicable deep learning for diagnosis and referral in retinal disease”. Nature Medicine (in press) (2018), DOI: 10.1038/s41591-018-0107-6

Ocular media opacities may sometimes cause artefactual reductions in OCT signal strength and this can make accurate image segmentation challenging. Due to localized reduction in OCT signal strength in this case, some of the models erroneously detect the presence of a partial thickness macular hole. As a result, the models are uncertain as to whether the eye is normal or whether routine referral is required.

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