How Marcelo and Megan solved a ten-year problem in minutes – Unfolded

Most people who have access to a modern healthcare system would not consider a disease like bubonic plague to be a threat. Such bacterial infections are usually dealt with easily through modern antibiotics. Yet antibiotic resistance, where bacteria evolve the ability to defeat these drugs, is fast becoming a growing global problem – and new antibiotics are thin on the ground.

Marcelo Sousa and Megan Mitchell at the University of Colorado Boulder are looking at a different approach: targeting the resistance mechanism itself, controlled in this case with enzymes.

As part of Unfolded, a series meeting the scientists using AlphaFold, Marcelo and Megan explain how they solved the structure of one such enzyme – a challenge that a decade of experimentation couldn’t complete – in minutes.

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