Hannah Fry speaks with Žiga Avsec and Adam Gayoso about models that predict how DNA sequence changes may affect molecular activity. They explain the relationship between genetic variation and cell behavior, and describe earlier AlphaGenome tools.
The researchers discuss AlphaGenome 2 predictions for specific cell types and a retrospective example involving a disease-associated variant. They emphasize that the models provide research clues, can miss important effects, and require experimental validationEvaluation is the systematic assessment of a system's behaviour or results against explicit criteria. rather than replacing clinical investigation.
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